Photo by Patrick Nizan

Learn | 10.12.2023

Weed And Nausea: Does Weed Actually Help?

Nausea, an unsettling and often debilitating sensation, can strike for a myriad of reasons—from migraines to motion sickness, from food poisoning to the after-effects of chemotherapy.

Historically, the quest for relief has led individuals to turn to an array of remedies. Among these, cannabis—more colloquially known as weed—stands out as a solution rooted in ancient traditions and now, increasingly, in modern medicine.

For millennia, different cultures across the world have harnessed the benefits of cannabis to counteract various ailments. Ancient Chinese texts, Egyptian papyrus scrolls, and Indian Ayurvedic practices all allude to cannabis’s therapeutic properties, particularly in alleviating pain and nausea. Fast forward to the present era, and amidst the renewed fervor around cannabis research, the pertinent question arises: Does weed scientifically and clinically help mitigate nausea?

The foundation of cannabis’s interaction with nausea lies in the intricate dance between the compounds in cannabis and the human endocannabinoid system. This complex network of receptors and neurotransmitters is woven throughout our bodies and plays a pivotal role in regulating a host of physiological processes, including our mood, appetite, and yes, our sensation of nausea and vomiting.

When we consume cannabis, its active compounds, particularly tetrahydrocannabinol (THC) and cannabidiol (CBD), bind with specific receptors in our endocannabinoid system. This binding event triggers a series of responses, one of which appears to be the suppression of nausea and vomiting, especially when these symptoms are side effects of chemotherapy, HIV treatments, or certain gastrointestinal ailments.

In contemporary times, the recognition of cannabis’s potential has led to its therapeutic use in modern medicine. For instance, the U.S. Food and Drug Administration (FDA) has approved medications like Dronabinol and Nabilone, both synthetic versions of THC, specifically for treating nausea and vomiting associated with chemotherapy when traditional treatments fail.

Yet, as with any burgeoning field of research, the full scope and limitations of cannabis as an anti-nausea solution remain subjects of intense study. Preliminary findings, combined with a rich tapestry of historical and anecdotal evidence, present a compelling narrative. But as science delves deeper, it seeks to parse fact from fiction, ensuring that individuals have clear, evidence-based guidance on turning to cannabis for nausea relief.

Weed Vs. Nausea

The dance between cannabis and nausea is a complicated one. Rooted in both age-old anecdotal experiences and modern scientific research, the potential effects of weed on nausea are a topic of keen interest. With a growing number of people seeking alternatives to traditional anti-nausea medications, it becomes essential to understand the science behind this relationship.

Understanding The Science

The human body, with its intricate systems and functions, has a unique way of responding to external compounds. At the heart of our understanding of weed’s effects on nausea is the endocannabinoid system (ECS). This biological system is composed of endocannabinoids, enzymes, and receptors—CB1 and CB2—that can be found throughout the body, particularly in the brain and the gastrointestinal system. When cannabis is consumed, its cannabinoids, primarily THC and CBD, interact with these receptors.

It’s this interaction that researchers believe can counteract nausea. The CB1 receptor, predominantly found in the brain, is the main target of THC. Activation of this receptor can influence various neurotransmitters that play roles in inducing or suppressing nausea. Some studies have shown that activation of CB1 receptors can lead to a reduction in serotonin release in the brain’s postrema area—a region associated with nausea and vomiting reflexes. This effect potentially accounts for the anti-nausea benefits observed in many cannabis users.

Weed’s Role In Alleviating Chemo, HIV, And Food Poisoning-Related Nausea

The therapeutic potential of cannabis is perhaps most visible in the realm of oncology. Chemotherapy, a lifeline for many cancer patients, unfortunately, comes with the challenging side effects of severe nausea and vomiting. This particular form of nausea—called chemotherapy-induced nausea and vomiting (CINV)—has been the focal point of several cannabis-related studies. Research has shown that both inhaled cannabis and oral THC preparations can be beneficial in mitigating CINV, with some patients preferring cannabis over conventional antiemetics.

Similarly, for patients with HIV/AIDS, where nausea can arise due to the disease itself or the antiretroviral therapy, cannabis has emerged as a potential relief source. Several reports indicate that cannabis use in this population not only helps in quelling nausea but also in improving appetite and overall quality of life.

Food poisoning, while differing vastly from the chronic nature of cancer or HIV, results in acute bouts of nausea and vomiting. Though there’s limited direct research on cannabis’s effects on food poisoning-induced nausea, the general anti-nausea properties of cannabinoids can be inferred to have potential benefits in such cases.

However, while the promise of cannabis in these scenarios is evident, it’s crucial to approach the subject with caution. Not everyone reacts to cannabis in the same way, and factors such as dosage, strain, and individual physiology can influence outcomes. The panorama of research underscores the potential of cannabis but also highlights the need for further, more nuanced studies to derive definitive conclusions.

Can Weed Actually Help Nausea?

For centuries, cultures worldwide have turned to cannabis for its purported therapeutic properties, with nausea relief being among its foremost applications. Today, as the lens of science sharpens its focus on this ancient remedy, we find ourselves pondering an old question with new urgency: Can weed genuinely provide relief from nausea?

Marijuana’s Therapeutic Promise

Delving into the heart of the matter, it’s essential to understand the broader perspective of how marijuana interacts with our body’s systems. As previously mentioned, the endocannabinoid system plays a crucial role. By modulating the release of certain neurotransmitters, marijuana can potentially provide relief from various symptoms—nausea being a primary one.

It’s not just about stopping the urge to vomit. The therapeutic promise of marijuana extends to treating associated symptoms that often accompany nausea.

Chronic Pain

Chronic pain, whether resulting from injury, surgery, or conditions like fibromyalgia, often comes hand-in-hand with nausea. Cannabis, especially strains high in CBD, has shown promise in providing analgesic effects. By potentially reducing pain, cannabis might indirectly alleviate nausea brought on by persistent pain.

Anxiety

Anxiety is another condition often intertwined with nausea. The sensation of unease or the dread associated with anxiety disorders can manifest physically as nausea. THC, in moderate doses, has shown potential anxiolytic (anxiety-reducing) properties. However, it’s worth noting that in higher doses, THC might exacerbate anxiety in some individuals. 

Appetite Reduction

For many facing chronic conditions or undergoing treatments like chemotherapy, loss of appetite is a common struggle—often further complicated by accompanying nausea. THC is known to stimulate appetite, a property that has been therapeutically harnessed, especially in HIV/AIDS patients. By promoting hunger and potentially reducing nausea, marijuana can assist in improving overall nutrient intake and health.

Fatigue

Nausea can be both a cause and a consequence of fatigue. Persistent nausea can lead to a reduced food intake, resulting in lowered energy levels and fatigue. Certain strains of cannabis, especially sativa-dominant ones, are known for their energizing effects, which could help combat fatigue and its associated nausea.

A Holistic View

It’s essential to approach the topic with a well-rounded perspective. While many individuals report significant relief from nausea and associated symptoms using cannabis, not all experiences are uniform. Dosage, strain selection, method of consumption, and individual physiological factors can significantly impact outcomes.

Moreover, potential interactions with other medications, the risk of dependency, and other side effects underscore the need for consultation with healthcare professionals. While cannabis holds undeniable therapeutic potential, it’s always best to navigate its benefits under informed guidance.

Best Marijuana Strains For Nausea

Navigating the verdant world of cannabis can be overwhelming, especially with the myriad of strains available, each boasting its unique properties. However, when it comes to nausea relief, some strains have risen to prominence due to their consistent effectiveness and user testimonials. Here’s a dive into some of the top contenders for nausea relief.

Harlequin

Profile: Sativa-dominant hybrid  

Key Cannabinoids: High CBD, Moderate THC  

Known for its high CBD content, Harlequin is a standout for those wary of the intoxicating effects of THC but seeking relief from nausea. Its unique cannabinoid profile ensures a clear-headed relief, making it suitable for daytime use. Moreover, the presence of CBD has been noted to provide anti-inflammatory and analgesic effects, potentially benefiting those with pain-induced nausea.

Sour Diesel

Profile: Sativa  

Key Cannabinoids: High THC

With a pungent aroma reminiscent of its namesake, Sour Diesel is a legendary sativa strain cherished for its invigorating effects. Many users vouch for its ability to curb nausea swiftly, especially that caused by anxiety or stress. Its uplifting effects can also counteract fatigue, making it a daytime favorite for many.

Blue Dream

Profile: Hybrid  

Key Cannabinoids: High THC

Blue Dream strikes a harmonious balance between sativa and indica genetics. It’s lauded for its swift action against nausea, coupled with a gentle cerebral invigoration that doesn’t overwhelm. Given its balanced nature, Blue Dream can be suitable for both daytime and evening use, assisting with appetite stimulation and relaxation alike.

Green Crack

Profile: Sativa  

Key Cannabinoids: High THC

Despite its somewhat controversial name, Green Crack is a powerhouse when it comes to rejuvenating effects. Famed for its ability to tackle fatigue and elevate mood, it’s also noted for its potential in reducing nausea. Those looking for a morning pick-me-up that simultaneously tackles queasiness might find a friend in Green Crack.

Final Thoughts On Strain Selection

Selecting the right strain for nausea isn’t solely about the strain itself but understanding one’s unique needs and how the strain fits into the broader picture. Factors like the time of day, the specific cause of nausea (be it pain, anxiety, or another factor), and individual tolerance levels play pivotal roles in determining the optimal choice.

Furthermore, it’s paramount to remember that cannabis affects everyone differently. A strain that offers profound relief to one individual might have subdued effects on another. Starting with small doses and noting the effects, perhaps in a journal, can guide users toward their ideal strain and dosage for nausea relief. Always remember to consult with a healthcare professional or a knowledgeable dispensary staff member before making any decisions.

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