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Health | 03.28.2023

5 Reasons Why Cannabis Affects Everyone Differently

Just like snowflakes, no two cannabis experiences are the same - because our biochemistry is as unique as our fingerprints!

Why do you and your friend react so differently to the same herb? It’s not just a matter of taste, my friend. Genetics, hormones, and more all play a part in how you feel after taking a puff.

Back in the 1960s, Israeli chemist Rafael Mechoulam threw a party and gave his friends 10mg of pure THC. What happened next? Chaos. Some were giggling uncontrollably, others were stuck in a paranoid frenzy, and one poor soul felt like her “psychological guards were breaking down.” Mechoulam realized that cannabis affects everyone differently, but it’s taken us until now to figure out why.

Turns out, genetics, gender, and even your menstrual cycle can all play a role in how you react to cannabis. So, the next time you and your pals are passing the joint around, don’t be surprised if you end up on different planets. At least you can bond over the fact that science still hasn’t solved the mystery of why that one friend always hogs the chips.

Here are 5 reasons why cannabis is the ultimate mystery box of highs.


Who would have thought that your genes could determine how you handle your weed?

Recent studies have shown that some of us may have a genetic mutation that makes us more prone to feeling anxious and paranoid after a few hits. It’s like our bodies are saying, “Hey, thanks for the buzz, but I’m feeling a little too high-strung right now.” And let’s not forget about the cognitive effects of cannabis. Your genes might make you more forgetful than your smoking buddy, so don’t feel bad if you can’t remember where you left your lighter.

But it’s not all bad news for the genetically inclined. Some lucky folks have a mutation that increases their natural levels of endocannabinoids – the body’s own version of THC and CBD. These endocannabinoids are like your personal stash of feel-good molecules, and having more of them means less anxiety and a reduced likelihood of experiencing withdrawal symptoms. It’s like winning the genetic lottery! So if you’re one of the lucky 20% with this mutation, maybe skip the joint and just enjoy your natural high.


Looks like Mother Nature has a few surprises up her sleeve when it comes to cannabis and gender. Men might have bigger appetites, but women reign supreme when it comes to sensitivity to the herb. Ladies, if you’re feeling “the pains,” cannabis might just be your new BFF. Sorry guys, you might have to double up on the greens for the same relief.

But you know there’s more! It turns out that even menstrual cycles can impact how the weedies are experienced too. THC and estrogen are like two peas in a pod, and the most powerful effects of cannabis kick in just as estrogen levels start to drop. Who knew hormones and herb could be such a dynamic duo?

Individualized Body Chemistry

When it comes to cannabis, we’re all a little different. It’s like a game of chance – you might roll a natural 20 and have an amazing high, or you might roll a one and end up feeling a little underwhelmed. Just like how some folks can’t handle their coffee or booze, some of us are more sensitive to the herb than others.

But fear not, dear space cadets! Your trusty endocannabinoid system is here to save the day once again. It turns out that genetics, diet, stress, and lifestyle can all impact your ECS and, thus, your high. So, if you’re not feeling the magic of the herb, maybe it’s time to hit up some omega-3-rich foods and give your endocannabinoid system the boost it desires. Remember, we’re all unique – and that’s what makes the cannabis experience so wonderfully diverse.

General Well-Being

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For those with PTSD or fibromyalgia, cannabis is like a superhero sidekick that helps them fight off their arch-nemesis of pain and anxiety. With a little bit of Mary Jane magic, they can finally feel like regular people again, ready to take on the world.

It’s all about that endocannabinoid tone. Cannabis swoops in to save the day, making sure that these superhero patients have their endocannabinoid systems working in tip-top shape. So, when it comes to fighting off chronic conditions, cannabis is the Robin to your endocannabinoid Batman.


Let’s take a toke at this one. It’s no secret that the more cannabis you smoke, the less you feel like you’re floating on a cloud. Your tolerance for the herb increases, and it takes a little more to get the same buzz going.

But if you’re a freshman in the ganja world, take heed! The plant’s potent effects can send you soaring to mars faster than Elon Musk if your body isn’t used to the THC-filled bliss yet, so buckle up and enjoy the ride.

Whether you’re a seasoned smoker or a curious newcomer, the way you experience cannabis depends on your unique factors. Your health, genetics, and lifestyle all play a role in how the herb will hit you. So, don’t be surprised if you and your buddy react differently to that same strain. Blame it on your biochemistry.

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