Terpenes For Pain Relief: What Works & Why

We’re not the first to call the cannabis plant fascinating. Between its cannabinoids, unique genetics, and countless natural compounds, there’s something for every user to appreciate.

But when it comes to pain relief, one group of compounds deserves special attention: terpenes.

If you’re wondering about the best terpenes for pain relief, this guide’s for you. Keep reading to learn how terpenes work, which ones can alleviate pain, and strains to keep on your radar.

Terpenes are the natural aromatic compounds responsible for giving plants—like cannabis— their distinct aromas.

While terpenes are found all throughout the plant kingdom and natural world, they are especially concentrated in cannabis plants and have been studied to produce therapeutic effects by interacting with the body’s endocannabinoid system.

On their own, terpenes don’t produce any intoxicating or psychoactive effects. But when combined with cannabinoids like THC, they contribute to the entourage effect—a phenomenon where terpenes and cannabinoids work in harmony together to enhance the overall effects produced by cannabis.

This synergy can potentially boost therapeutic benefits, such as pain relief, anti-inflammation, relaxation, or even heightened focus.

Yes, terpenes are believed to provide pain relief through their analgesic and anti-inflammatory properties.

By interacting with receptors involved in pain perception—such as TRPV1 receptors and cannabinoid receptors like CB1 and CB2—terpenes can influence how pain signals are processed and perceived by the brain, potentially reducing their intensity and providing relief.

Certain terpenes have been studied to alleviate pain across various conditions, including:

• Inflammatory pain
• Neuropathic pain
• Acute pain

Since terpenes are naturally occurring, many consider them more appealing as a pain relief aid than traditional over-the-counter medications.

This is the most common terpene found in cannabis strains. It’s earthy, musky, and well-loved for its potent anti-inflammatory properties that make it excellent for pain relief.

You might notice that your product’s packaging notes Myrcene as the dominant terpene. If that’s the case, expect it to function as a muscle relaxant, which may help with chronic pain (especially joint pain) and discomfort in the musculoskeletal system.

Beta-caryophyllene is pretty impressive. It’s the only terpene that directly binds to the same cannabinoid receptors. While other terpenes bind to different cell receptors, this one clings to the same receptors that the cannabinoids like THC and CBD do.

It’s bitter, citrusy, and praised for its strong anti-inflammatory effects in treating chronic pain. Additionally, since it binds directly to CB2 receptors, it’s especially effective for neuropathic pain without causing a “buzz” or intoxicating, psychoactive effects.

Linalool is a personal favorite of mine, and it’s no wonder why—this terpene is what gives lavender its signature soothing, floral aroma.

Studies have shown that linalool can help reduce pain sensitivity and suppress inflammatory pain. And with effects that range from enhanced pain relief to anxiety reduction, it’s no surprise that linalool is one of the most sought-after terpenes around.

This is another highly abundant terpene in cannabis that many adore for its zesty, lemon-like, citrusy aroma.

Beyond its refreshing scent, limonene offers significant anti-inflammatory benefits while also supporting the immune system. Some research points out that limonene might be beneficial for alleviating symptoms from digestive and kidney diseases that produce inflammatory pain.

Outside of cannabis, alpha-pinene is one of the most commonly found terpenes in the natural world. Better yet, it’s been studied and sought after for its impressive analgesic and therapeutic properties.

Its scent is like fresh pine, and it works especially well for reducing inflammation caused by joint pain. Its aroma might even have respiratory benefits that complement its pain-relieving effects.

Interested in growing your own terpene-rich cannabis flower? For best results, do it with a reputable seed bank.

ILGM’s impressive catalog of seeds has yet to let us down. Whether you’re after feminized seeds, easy auto flowers, or even more complex varieties, this Home of the Growers has something for everyone.

Below, we’ve included a few of ILGM’s top-rated strains in the terpene department. Grow these seeds into healthy, mature, flower-packed plants with your chosen terpenes for a truly customized experience. See the selection below.

Terpenes: Humulene, D-Limonene, beta-Pinene, Myrcene, Valencene, Carene

THC: 21%

Difficulty: Easy

Taste/Aroma: Berry, Candy, Citrus, Fruity, Grape, Grapefruit, Sweet

What To Expect: Zkittlez is an Indica-dominant plant with relaxing, balanced hybrid effects that dance the line between calming and motivating.

Terpenes: Myrcene, Caryophyllene, Limonene, Linalool, a-Pinene

THC: 20%

Difficulty: Moderate

Taste/Aroma: Citrus, Diesel, Earthy, Herbal, Lemon, Pine, Spice

What To Expect: Skywalker OG gives off a stunning visual appearance thanks to parent strains Skywalker and OG Kush. Expect a powerful Inica-dominant buzz with about 80% Indica and 20% Sativa presence.

Terpenes: Caryophyllene, Limonene, Pinene, Myrcene, Terpinolene

THC: 32%

Difficulty: Moderate

Taste/Aroma: Apple, Citrus, Diesel, Earthy, Sweet, Sour

What To Expect: Apple Fritter is incredibly potent with a high THC content and offers a well-balanced Hybrid buzz, perfect for kicking back with a lifted mood and clear-headed effects.

Terpenes: Myrcene, Caryophyllene, beta-Pinene, D-Limonene, Ocimene

THC: 28%

Difficulty: Easy

Taste/Aroma: Fruity, Grape, Pine, Skunky, Sweet, Woody

What To Expect: Godfather OG is well-loved for a variety of reasons. This potent Indica hits hard with a high THC content and deeply relaxing effects, making it great for stress relief or a general sense of bliss.

Terpenes: Myrcene, Caryophyllene, D-Limonene, Carene, Humulene, alpha-Bisabolol, alpha-Pinene, Geraniol, Terpineol, Ocimene, Linalool

THC: 24%

Difficulty: Easy

Taste/Aroma: Berry, Earthy, Spicy, Sweet

What To Expect: Purple Haze is an iconic strain. It’s named after one of Jimi Hendrix’s biggest hits. Beyond its stunning visuals, it’s a Sativa-leaning strain with a high THC content for an uplifting, calming, motivating buzz.

Is one terpene considered “the best” for pain?

While all pain-relieving terpenes offer benefits, beta-caryophyllene is definitely the top choice for pain relief. It’s the only cannabinoid that binds directly to cannabinoid receptors, meaning it works in a similar fashion to cannabis without causing psychoactive effects.

That said, the most effective approach for pain relief involves multiple terpenes and cannabinoids to produce the beloved entourage effect mentioned earlier.

Which terpene is good for arthritis?

Myrcene and beta-caryophyllene are likely the most effective for arthritis pain. These terpenes have potent anti-inflammatory properties that target joint pain directly.

What terpene relaxes muscles?

Myrcene is the strongest muscle relaxant in the world of cannabis terpenes. It helps relieve pain thanks to its sedative and relaxing effects.

What are the negative side effects of terpenes?

Terpenes don’t often cause side effects when used appropriately. That means in proper doses, following the packaging instructions, or simply enjoying cannabis strains as you normally would.

However, some people might experience mild reactions like skin irritation or respiratory irritation with certain terpenes. But for the most part, terpenes don’t produce unwanted side effects.

In high doses, you could experience dizziness, headaches, and digestive issues. Though these are pretty rare when using terpenes in regular doses.

What are the most common terpenes in weed?

Myrcene, limonene, caryophyllene, pinene, and linalool are the most common Cannabis sativa terpenes. They all provide slightly different effects with vastly different aromas.

Check out our article on cannabis terpenes to learn more about their unique scents and effects.