There’s always time to tell a friend about an interesting factoid you’ve learned about marijuana. Whether you want to read more about your favorite plant or share some random knowledge with your buds, we’ve created a list of five interesting marijuana facts to keep your conversations flowing.

Okay, maybe he wasn’t a true cannabis connoisseur, but forensic technology has shown that some of his clay pipes had traces of marijuana in his Stratford-upon-Avon garden. The study that discovered this used a gas procedure to highlight the traces of marijuana residue that dated back hundreds of years. So maybe Shakespeare was a little lifted when writing his legendary plays, sonnets, and other creations.

In a 2016 study on The Use of Medical Marijuana in Cancer, researchers found that cannabinoids are able to reduce the size of malignant tumors by killing individual cancer cells. While studies like these are popping up left and right, the FDA still does not deem marijuana or related compounds an approved cancer treatment.

Washington State University published a study in 2014 that looks at how female rats reacted differently to THC than male rats. Because female rats also have a menstrual cycle, this made it easier to tell how female humans might react to THC. The study reads that female rats were not only more sensitive to THC when ovulating, but it only took ten days for female rats to build a higher tolerance than male rats. This means that with a week of toking, women could out-smoke even the most experienced male users.

On the island of Svalbard, just between Norway and the North Pole, there’s a Doomsday Vault packed with about 20,000 cannabis seeds donated from almost every country. That said, the Doomsday Vault actually carries 850,000 seeds spanning all sorts of plant species. The vault is said to be “catastrophe proof,” and all the cannabis seeds inside are from a unique individual strain.