It is not uncommon to hear a cannabis enthusiast mention that cannabidiol (CBD) is nonpsychoactive. However, is this claim really true? The compound doesn’t cause the euphoric high well-known to herb lovers around the world. However, CBD can have an effect on your mood, emotions, and mind. Here’s more information on how CBD interacts with the brain.
CBD does not cause the mind-altering “high” that is often sought out amongst cannabis consumers. It’s another compound, tetrahydrocannabinol (THC), that causes the mind-altering effects for which the herb is famous.
It is for this reason that CBD is not considered psychoactive. However, the compound does have an effect the brain and your mood. This means that some professionals argue that CBD is technically psychoactive.
CBD and THC both engage the brain in different ways. THC binds directly to special locations in the cell known as cannabinoid receptors. These receptors were named after the active compounds in cannabis, called cannabinoids. Both THC and CBD are cannabinoids.
THC directly engages cannabinoid receptors, causing a near immediate psychoactive high. CBD, however, engages a different location on these receptors (like a side pocket).
While CBD does not produce a stand-apart psychoactive experience by connecting with this location, the molecule does alter the effects of other compounds that try to link up to the same spot.
While CBD is not psychoactive in the recreational sense, the cannabinoid certainly does have an affect on the brain.
The exact effects of CBD on the brain and body are still awaiting discovery. However, over the past decade, researchers have unveiled some of the amazing ways CBD affects the brain and produces therapeutic effects.
To give you a sense of the CBD experience, here are three ways that CBD is psychoactive:
Feeling blue? Pre-clinical studies have shown that CBD causes a rapid increase in serotonin, the same compound targeted by antidepressants.
The cannabinoid engages a certain cell receptor, the 5HT1A receptor, which is one several serotonin receptors in the human brain.
This early rodent research is quite promising, as commonly prescribed drugs can take as long as six weeks to produce therapeutic effects. In other research areas, cannabis is considered well-tolerated in humans. This is perhaps why many cannabis patients gravitate to the herb when they’re feeling more than a little bit down.
CBD also helps prevent the breakdown of feel-good endocannabinoids, which may boost mood and generate feelings of bliss and contentment, sort of like a runner’s high.
CBD also has the ability to quickly and dramatically ease anxiety. In fact, has such strong anxiolytic effects that it has shown success as an anti-psychotic in early human trials.
Trials were conducted in patients with treatment-resistant schizophrenia and used CBD isolate in conjunction with conventional medications.
Another small human study conducted in 2011 found that pre-treatment of CBD prior to a public speaking event limited the levels of reported anxiety among 12 patients that had not used CBD before. They were given 600 mg of the compound.
Human trials have found that CBD is a powerful anti-seizure medication, quieting excitability in the brain. Though the cannabinoid is considered nonpsychoactive, CBD has been shown to have a drastic effect on the brain of those with certain types of epilepsy.
Pediatric epileptic conditions like Dravet Syndrome and Lennox-Gastaut Syndrome have been found to be particularly responsive to the effects of THC. In case videos, children in the midst of seizure are pulled back just a few moments after being given a few drops of medical cannabis oil.
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